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KMID : 1130320080510050523
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Korean Journal of Pediatrics
2008 Volume.51 No. 5 p.523 ~ p.527
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Transforming growth factor-β gene promoter polymorphism:its association with renal involvement in Henoch-Scholein Purpura in childhood
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Lee Seung-Ho
Jee Hwa-Young
Kim Hwang-Min
Yeh Byung-Il
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Abstract
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Purpose: Several cytokines play important roles in the inflammatory process of Henoch-Scholein Purpura (HSP). It is likely that transforming growth factor-β (TGF-β) is involved in the pathogenesis of HSP. The purpose of this study is to investigate whether TGF-β promoter polymorphism is associated with the renal involvement of childhood HSP.
Methods: Thirty-four patients younger than 15 years, who had been diagnosed with HSP, as well as 27 controls, were examined. Patients and controls were genotyped for TGF-β C-509T by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Results: The T allelic frequencies in patients and controls showed no difference (45% vs. 48.8%). No allele or genotype differences between the group of HSP group and control group were observed. The frequencies of TGF-β 509 genotypes TT, TC, and CC were no different between patients and controls (26% vs. 22%). The TT genotype of polymorphism of the TGF-β C-509T gene had no relation to the susceptibility of children to HSP and renal involvement in HSP.
Conclusion: TGF-β T allele may not be related to the susceptibility of children to HSP. The TT genotype of polymorphism of the TGF-β C 509T gene does not appear to have an influence on renal involvement in childhood HSP.
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KEYWORD
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Henoch-Scholein Purpura, TGF-β polymorphism, Renal involvement
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